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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735328
Species: Homo sapiens
RGD Object: Gene
Symbol: PLA2G5
Name: phospholipase A2 group V
Acc ID: CHEBI:53490
Term: N-formyl-L-methionyl-L-leucyl-L-phenylalanine
Definition: A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.
Chemical ID: MESH:D009240
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLA2G5increases activityEXP 6480464CTDN-Formylmethionine Leucyl-Phenylalanine results in increased activity of PLA2G5 proteinPMID:11741884
PLA2G5increases secretionEXP 6480464CTDN-Formylmethionine Leucyl-Phenylalanine results in increased secretion of PLA2G5 proteinPMID:11741884
PLA2G5multiple interactionsEXP 6480464CTDPLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Arachidonic Acid]; PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]PMID:9495842
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