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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732740
Species: Homo sapiens
RGD Object: Gene
Symbol: CAT
Name: catalase
Acc ID: CHEBI:8630
Term: pterostilbene
Definition: A stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'.
Chemical ID: MESH:C107773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CATincreases expressionEXP 6480464CTDpterostilbene results in increased expression of CAT mRNAPMID:25341683
CATmultiple interactionsEXP 6480464CTDCAT protein inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased activity of CASP4 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA]; CAT protein inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of NQO1 mRNA]; CAT protein inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; pterostilbene inhibits the reaction [Ethanol results in decreased activity of CAT protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased activity of CAT protein]]PMID:25341683 PMID:34474091
CATmultiple interactionsISOCat (Mus musculus)6480464CTDpterostilbene inhibits the reaction [Streptozocin results in decreased expression of CAT]PMID:26700463
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