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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732740
Species: Homo sapiens
RGD Object: Gene
Symbol: CAT
Name: catalase
Acc ID: CHEBI:7959
Term: D-penicillamine
Definition: An optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning.
Chemical ID: MESH:D010396
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CATdecreases expressionEXP 6480464CTDPenicillamine results in decreased expression of CAT mRNAPMID:22843330
CATmultiple interactionsEXP 6480464CTD[Penicillamine co-treated with ATP7B gene mutant form] results in decreased activity of CAT proteinPMID:24368744
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