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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731823
Species: Homo sapiens
RGD Object: Gene
Symbol: ECE1
Name: endothelin converting enzyme 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ECE1affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of ECE1 intron; Benzo(a)pyrene affects the methylation of ECE1 promoterPMID:27901495 PMID:30157460
ECE1increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of ECE1 3' UTRPMID:27901495
ECE1multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of ECE1 mRNA; [Benzo(a)pyrene co-treated with 1-methylphenanthrene] affects the expression of ECE1 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of ECE1 mRNA; [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of ECE1 mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of ECE1 mRNAPMID:17690111
ECE1decreases expressionISOEce1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ECE1 mRNAPMID:19770486
ECE1decreases methylationISOEce1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of ECE1 intronPMID:27901495
ECE1increases expressionISOEce1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ECE1 mRNAPMID:20127859
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