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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731392
Species: Homo sapiens
RGD Object: Gene
Symbol: ATP7B
Name: ATPase copper transporting beta
Acc ID: CHEBI:15430
Term: protoporphyrin
Definition: A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.
Chemical ID: MESH:C028025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATP7Bdecreases chemical synthesisEXP 6480464CTDATP7B gene mutant form results in decreased chemical synthesis of protoporphyrin IXPMID:19888908
ATP7Bmultiple interactionsEXP 6480464CTDATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of protoporphyrin IX]PMID:19888908
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