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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731367
Species: Homo sapiens
RGD Object: Gene
Symbol: TRPV6
Name: transient receptor potential cation channel subfamily V member 6
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TRPV6affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of TRPV6 promoterPMID:27901495
TRPV6decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of TRPV6 exonPMID:27901495
TRPV6increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of TRPV6 3' UTRPMID:27901495
TRPV6increases expressionISOTrpv6 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of TRPV6 mRNAPMID:23735875
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