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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70972
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hao2
Name: hydroxyacid oxidase 2
Acc ID: CHEBI:63613
Term: nevirapine
Definition: A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.
Chemical ID: MESH:D019829
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hao2decreases expressionEXP 6480464CTDNevirapine metabolite results in decreased expression of HAO2 mRNA; Nevirapine results in decreased expression of HAO2 mRNAPMID:23947594
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