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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69321
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hadh
Name: hydroxyacyl-CoA dehydrogenase
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hadhincreases expressionEXP 6480464CTDCisplatin results in increased expression of HADH proteinPMID:22023808
Hadhincreases phosphorylationISOHadh (Mus musculus)6480464CTDCisplatin results in increased phosphorylation of HADH proteinPMID:22006019
Hadhmultiple interactionsISOHADH (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of HADH mRNAPMID:27392435
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