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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67402
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox2
Name: heme oxygenase 2
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox2decreases expressionISOHMOX2 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in decreased expression of HMOX2 mRNAPMID:27509014
Hmox2decreases response to substanceISOHMOX2 (Homo sapiens)6480464CTDHMOX2 protein results in decreased susceptibility to tert-ButylhydroperoxidePMID:15589375
Hmox2increases methylationISOHMOX2 (Homo sapiens)6480464CTDtert-Butylhydroperoxide results in increased methylation of HMOX2 genePMID:27509014
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