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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628900
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sorbs3
Name: sorbin and SH3 domain containing 3
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sorbs3affects response to substanceISOSORBS3 (Homo sapiens)6480464CTDSORBS3 protein affects the susceptibility to sodium arsenitePMID:25237887
Sorbs3multiple interactionsISOSorbs3 (Mus musculus)6480464CTD[MAPK8 protein mutant form results in decreased phosphorylation of and results in decreased activity of MAPK8 protein] inhibits the reaction [sodium arsenite promotes the reaction [CPEB4 protein binds to SORBS3 protein]]; pyrazolanthrone inhibits the reaction [sodium arsenite promotes the reaction [CPEB4 protein binds to SORBS3 protein]]; sodium arsenite promotes the reaction [CPEB4 protein binds to SORBS3 protein]PMID:25237887
Sorbs3multiple interactionsISOSORBS3 (Homo sapiens)6480464CTDsodium arsenite inhibits the reaction [VCL protein binds to SORBS3 protein]PMID:25237887
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