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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628719
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp4x1
Name: cytochrome P450, family 4, subfamily x, polypeptide 1
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp4x1decreases expressionISOCYP4X1 (Homo sapiens)6480464CTDCalcitriol results in decreased expression of CYP4X1 mRNAPMID:27107558
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