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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621780
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dkc1
Name: dyskerin pseudouridine synthase 1
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dkc1multiple interactionsISODKC1 (Homo sapiens)6480464CTDafimoxifene inhibits the reaction [Estrogens results in increased expression of DKC1 mRNA]PMID:21233418
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