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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhcr7
Name: 7-dehydrocholesterol reductase
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhcr7multiple interactionsEXP 6480464CTD[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of DHCR7 mRNAPMID:25055962
Dhcr7affects expressionISODHCR7 (Homo sapiens)6480464CTDSimvastatin affects the expression of DHCR7 mRNAPMID:28975700
Dhcr7affects response to substanceISODHCR7 (Homo sapiens)6480464CTDDHCR7 mutant form affects the susceptibility to SimvastatinPMID:19365639
Dhcr7multiple interactionsISODHCR7 (Homo sapiens)6480464CTDHydroxychloroquine affects the reaction [Simvastatin affects the expression of DHCR7 mRNA]; Simvastatin promotes the reaction [DHCR7 results in increased chemical synthesis of Cholesterol]PMID:15896653 PMID:28975700
Dhcr7multiple interactionsISODhcr7 (Mus musculus)6480464CTDSimvastatin inhibits the reaction [DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol]PMID:16446309
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