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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621769
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhcr7
Name: 7-dehydrocholesterol reductase
Acc ID: CHEBI:16113
Term: cholesterol
Definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
Chemical ID: MESH:D002784
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhcr7affects response to substanceISODHCR7 (Homo sapiens)6480464CTDDHCR7 mutant form affects the susceptibility to CholesterolPMID:19365639
Dhcr7decreases abundanceISODHCR7 (Homo sapiens)6480464CTDDHCR7 mutant form results in decreased abundance of CholesterolPMID:16446309
Dhcr7increases chemical synthesisISODHCR7 (Homo sapiens)6480464CTDDHCR7 results in increased chemical synthesis of CholesterolPMID:15896653
Dhcr7multiple interactionsISODHCR7 (Homo sapiens)6480464CTDSimvastatin promotes the reaction [DHCR7 results in increased chemical synthesis of Cholesterol]PMID:15896653
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