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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621728
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smarca4
Name: SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smarca4decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SMARCA4 mRNAPMID:33387578
Smarca4increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SMARCA4 mRNAPMID:18796159
Smarca4affects expressionISOSmarca4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SMARCA4 mRNAPMID:21570461
Smarca4multiple interactionsISOSMARCA4 (Homo sapiens)6480464CTDSMARCA4 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [SMARCA4 protein binds to CYP1A1 enhancer]; Tetrachlorodibenzodioxin promotes the reaction [SMARCA4 protein binds to CYP1A1 promoter]; Tetrachlorodibenzodioxin promotes the reaction [SMARCA4 protein binds to CYP1B1 enhancer]; Tetrachlorodibenzodioxin promotes the reaction [SMARCA4 protein binds to CYP1B1 promoter]PMID:18842620
Smarca4multiple interactionsISOSmarca4 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMARCA4 mRNAPMID:17942748
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