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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621389
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slco1a4
Name: solute carrier organic anion transporter family, member 1a4
Acc ID: CHEBI:4551
Term: digoxin
Definition: A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.
Chemical ID: MESH:D004077
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slco1a4decreases activityEXP 6480464CTDDigoxin results in decreased activity of SLCO1A4 proteinPMID:11883641
Slco1a4increases uptakeEXP 6480464CTDSLCO1A4 protein results in increased uptake of DigoxinPMID:11883641
Slco1a4multiple interactionsEXP 6480464CTDDigoxin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Quinine inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]; Rifampin inhibits the reaction [SLCO1A4 protein results in increased uptake of Digoxin]PMID:11883641
Slco1a4affects transportISOSlco1a4 (Mus musculus)6480464CTDSLCO1A4 protein affects the transport of DigoxinPMID:19833843
Slco1a4multiple interactionsISOSlco1a4 (Mus musculus)6480464CTDDigoxin inhibits the reaction [SLCO1A4 protein results in increased uptake of epyrifenacil metabolite]; Elacridar affects the reaction [SLCO1A4 protein affects the transport of Digoxin]PMID:19833843 PMID:34619012
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