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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621389
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slco1a4
Name: solute carrier organic anion transporter family, member 1a4
Acc ID: CHEBI:32270
Term: trospium chloride
Definition: An organic chloride salt of trospium. It is an antispasmodic drug used for the treatment of overactive bladder.
Chemical ID: MESH:C003330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slco1a4decreases activityISOSLCO1A2 (Homo sapiens)6480464CTDtrospium chloride results in decreased activity of SLCO1A2 protein; trospium chloride results in decreased activity of SLCO1A2 protein alternative formPMID:25466967
Slco1a4increases metabolic processingISOSLCO1A2 (Homo sapiens)6480464CTDSLCO1A2 protein results in increased metabolism of trospium chloridePMID:25466967
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