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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621248
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acaca
Name: acetyl-CoA carboxylase alpha
Acc ID: CHEBI:47612
Term: bezafibrate
Definition: A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Chemical ID: MESH:D001629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acacadecreases expressionISOAcaca (Mus musculus)6480464CTDBezafibrate results in decreased expression of ACACA mRNA; Bezafibrate results in decreased expression of ACACA proteinPMID:19124612
Acacaincreases expressionISOAcaca (Mus musculus)6480464CTDBezafibrate results in increased expression of ACACA mRNA; Bezafibrate results in increased expression of ACACA proteinPMID:19124612
Acacamultiple interactionsISOAcaca (Mus musculus)6480464CTDPPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA protein]PMID:19124612
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