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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621127
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dpp3
Name: dipeptidylpeptidase 3
Acc ID: CHEBI:89656
Term: Leu-enkephalin
Definition: A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.
Chemical ID: MESH:D004743
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dpp3increases cleavageISODPP3 (Homo sapiens)6480464CTDDPP3 protein results in increased cleavage of Enkephalin, LeucinePMID:10873616
Dpp3multiple interactionsISODPP3 (Homo sapiens)6480464CTDspinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]PMID:10873616
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