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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620822
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Polr1b
Name: RNA polymerase I subunit B
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Polr1bincreases expressionEXP 6480464CTDbisphenol A results in increased expression of POLR1B mRNAPMID:25181051 PMID:30816183 PMID:34947998
Polr1bincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of POLR1B genePMID:28505145
Polr1bdecreases expressionISOPolr1b (Mus musculus)6480464CTDbisphenol A results in decreased expression of POLR1B mRNAPMID:26063408
Polr1bdecreases methylationISOPolr1b (Mus musculus)6480464CTDbisphenol A results in decreased methylation of POLR1B promoterPMID:27312807
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