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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620722
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Zfp36
Name: zinc finger protein 36
Acc ID: CHEBI:173086
Term: ferrostatin-1
Definition: An ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals.
Chemical ID: MESH:C573944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Zfp36multiple interactionsISOZfp36 (Mus musculus)6480464CTDferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of ZFP36 mRNA]; ferrostatin-1 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of ZFP36 protein]PMID:36435477
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