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GENE - TERM ANNOTATION REPORT

RGD ID: 620605
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Zp2
Name: zona pellucida glycoprotein 2
Acc ID: DOID:9001599
Term: Oocyte/Zygote/Embryo Maturation Arrest 6
Definition: Oocyte maturation defect-6 (OOMD6) is characterized by primary infertility due to defective sperm-binding to an abnormally thin zona pellucida in patient oocytes. Successful pregnancy may be achieved by intracytoplasmic sperm injection in these patients. OOMD6 is caused by homozygous mutation in the ZP2 gene on chromosome 16p12. (OMIM)
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Zp2 ISOZP2 (Homo sapiens)7240710OMIM  
Zp2 ISOZP2 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Oocyte maturation defect 6 | ClinVar Annotator: match by term: ZP2-related conditionPMID:25741868 PMID:28492532 PMID:28971300 PMID:29895852 PMID:30810869 PMID:35211729
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