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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620555
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mt-nd1
Name: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Acc ID: CHEBI:76004
Term: dimethyl fumarate
Definition: An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis.
Chemical ID: MESH:C056020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mt-nd1increases expressionISOmt-Nd1 (Mus musculus)6480464CTDDimethyl Fumarate results in increased expression of ND1 mRNAPMID:27277809
Mt-nd1multiple interactionsISOmt-Nd1 (Mus musculus)6480464CTDNFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND1 mRNA]PMID:27277809
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