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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620555
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mt-nd1
Name: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Acc ID: CHEBI:3259
Term: CCCP
Definition: A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.
Chemical ID: MESH:D002258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mt-nd1decreases expressionISOMT-ND1 (Homo sapiens)6480464CTDCarbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of ND1 proteinPMID:34481905
Mt-nd1multiple interactionsISOMT-ND1 (Homo sapiens)6480464CTDDeoxyglucose inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of ND1 protein]PMID:34481905
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