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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620040
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prdx3
Name: peroxiredoxin 3
Acc ID: CHEBI:231347
Term: triapine
Definition: A thiosemicarbazone resulting from the formal condensation of the formyl group of 3-aminopicolinaldehyde with the non-thioacylated amino group of hydrazinecarbothioamide. It is a ribonucleotide reductase inhibitor that exhibits anti-cancer properties.
Chemical ID: MESH:C078157
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prdx3increases oxidationISOPRDX3 (Homo sapiens)6480464CTD3-aminopyridine-2-carboxaldehyde thiosemicarbazone results in increased oxidation of PRDX3 proteinPMID:21195754
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