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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61855
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Acc ID: CHEBI:4910
Term: etomidate
Definition: The ethyl ester of 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid. It is an intravenous general anaesthetic with no analgesic activity.
Chemical ID: MESH:D005045
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gabra1multiple interactionsEXP 6480464CTDEtomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Etomidate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]PMID:12939268
Gabra1multiple interactionsISOGABRA1 (Homo sapiens)6480464CTDEtomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRE]]; Etomidate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 binds to GABRB1 binds to GABRG2]]PMID:10049148
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