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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61306
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspb1
Name: heat shock protein family B (small) member 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspb1increases phosphorylationEXP 6480464CTDStreptozocin results in increased phosphorylation of HSPB1 proteinPMID:34414639
Hspb1multiple interactionsEXP 6480464CTDbaicalin inhibits the reaction [Streptozocin results in increased phosphorylation of HSPB1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of HSPB1 protein]PMID:18204486 PMID:34414639
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