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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Zeb1
Name: zinc finger E-box binding homeobox 1
Acc ID: CHEBI:83784
Term: galaxolide
Definition: An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics.
Chemical ID: MESH:C033119
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Zeb1increases expressionISOZEB1 (Homo sapiens)6480464CTDgalaxolide results in increased expression of ZEB1 mRNAPMID:34687775
Zeb1multiple interactionsISOZEB1 (Homo sapiens)6480464CTDacetyl methyl tetramethyl tetralin promotes the reaction [galaxolide results in increased expression of ZEB1 mRNA]; galaxolide promotes the reaction [acetyl methyl tetramethyl tetralin results in increased expression of ZEB1 mRNA]PMID:34687775
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