GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Slc1a3 | increases expression | EXP | | 6480464 | CTD | Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA; Raloxifene Hydrochloride results in increased expression of SLC1A3 protein | PMID:24782323 | Slc1a3 | multiple interactions | EXP | | 6480464 | CTD | [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein]; [Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein; ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 protein]; Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 protein] | PMID:24782323 | | ||||||||||||||||||||||
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