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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3535
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rarb
Name: retinoic acid receptor, beta
Acc ID: CHEBI:6067
Term: isotretinoin
Definition: A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases.
Chemical ID: MESH:D015474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rarbdecreases expressionEXP 6480464CTDIsotretinoin results in decreased expression of RARB mRNAPMID:19041696
Rarbincreases expressionEXP 6480464CTDIsotretinoin results in increased expression of RARB mRNAPMID:19041696
Rarbincreases expressionISORARB (Homo sapiens)6480464CTDIsotretinoin results in increased expression of RARB mRNAPMID:17486130
Rarbmultiple interactionsISORARB (Homo sapiens)6480464CTD[LAQ824 co-treated with Isotretinoin] results in increased acetylation of RARB promoter; [LAQ824 co-treated with Isotretinoin] results in increased expression of RARB mRNA; R116010 promotes the reaction [Isotretinoin results in increased expression of RARB mRNA]PMID:17237267 PMID:17486130
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