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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3535
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rarb
Name: retinoic acid receptor, beta
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rarbdecreases metabolic processingISORARB (Homo sapiens)6480464CTDepigallocatechin gallate results in decreased metabolism of RARB promoterPMID:16037419
Rarbdecreases methylationISORARB (Homo sapiens)6480464CTDepigallocatechin gallate results in decreased methylation of RARB promoterPMID:14633667
Rarbincreases expressionISORARB (Homo sapiens)6480464CTDepigallocatechin gallate results in increased expression of RARB mRNA; epigallocatechin gallate results in increased expression of RARB proteinPMID:14633667
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