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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3529
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rab4a
Name: RAB4A, member RAS oncogene family
Acc ID: CHEBI:3558
Term: cerivastatin
Definition: (3R,5S)-3,5-dihydroxyhept-6-enoic acid in which the (7E)-hydrogen is substituted by a 4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl group. Formerly used (as its sodium salt) to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.
Chemical ID: MESH:C086276
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rab4aaffects expressionEXP 6480464CTDcerivastatin affects the expression of RAB4A proteinPMID:16239165
Rab4adecreases prenylationEXP 6480464CTDcerivastatin results in decreased prenylation of RAB4 proteinPMID:16239165
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