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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:8378
Term: prednisolone
Definition: A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Chemical ID: MESH:D011239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngdecreases expressionEXP 6480464CTDPrednisolone results in decreased expression of IFNG mRNAPMID:11043609
Ifngmultiple interactionsEXP 6480464CTDPrednisolone inhibits the reaction [Amiodarone results in decreased expression of IFNG protein]PMID:34590760
Ifngdecreases expressionISOIfng (Mus musculus)6480464CTDPrednisolone results in decreased expression of IFNG proteinPMID:15821026
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTDPrednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG mRNA]; Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG protein]PMID:23133493
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