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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngaffects secretionISOIfng (Mus musculus)6480464CTDToluene 2,4-Diisocyanate affects the secretion of IFNG proteinPMID:19150644
Ifngdecreases expressionISOIfng (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in decreased expression of IFNG mRNA; Toluene 2,4-Diisocyanate results in decreased expression of IFNG proteinPMID:12356572 PMID:16271432
Ifngincreases expressionISOIfng (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in increased expression of IFNG mRNA; Toluene 2,4-Diisocyanate results in increased expression of IFNG proteinPMID:10637130 PMID:11243917 PMID:12884401 PMID:15588918 PMID:15590890 PMID:17014439 PMID:17641053 PMID:17980417 PMID:18242016 PMID:18652873 PMID:19042193 PMID:19422874 PMID:19428947 PMID:20219652 PMID:21404309 PMID:28826779
Ifngincreases secretionISOIfng (Mus musculus)6480464CTDToluene 2,4-Diisocyanate results in increased secretion of IFNG proteinPMID:28329851 PMID:31577921
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTDCD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG mRNA]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IFNG protein]; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IFNG protein]PMID:15590890 PMID:17014439 PMID:28329851 PMID:31577921
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