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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngdecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of IFNG proteinPMID:24954678
Ifngmultiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IFNG protein; Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased expression of IFNG protein]PMID:24954678 PMID:35489423
Ifngdecreases activityISOIFNG (Homo sapiens)6480464CTDCadmium Chloride results in decreased activity of IFNG proteinPMID:19635391
Ifngdecreases expressionISOIfng (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of IFNG mRNAPMID:23503628
Ifngdecreases secretionISOIfng (Mus musculus)6480464CTDCadmium Chloride results in decreased secretion of IFNG proteinPMID:17706638
Ifngincreases expressionISOIFNG (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of IFNG proteinPMID:26138014
Ifngincreases expressionISOIfng (Mus musculus)6480464CTDCadmium Chloride results in increased expression of IFNG mRNA; Cadmium Chloride results in increased expression of IFNG proteinPMID:23038000 PMID:25528414 PMID:7536360
Ifngincreases secretionISOIFNG (Homo sapiens)6480464CTDCadmium Chloride results in increased secretion of IFNG proteinPMID:30572105
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IFNG protein]; Cadmium Chloride inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Cadmium Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]PMID:11076874 PMID:16843830 PMID:26138014
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTDbutane-2,3-dione thiosemicarbazone oxime inhibits the reaction [Cadmium Chloride results in increased expression of IFNG protein]; lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [Cadmium Chloride results in increased expression of IFNG mRNA]; piperidine inhibits the reaction [Cadmium Chloride results in decreased secretion of IFNG protein]PMID:17706638 PMID:23038000 PMID:7536360
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