Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngmultiple interactionsEXP 6480464CTDGenistein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased abundance of Nitric Oxide]; Genistein promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein co-treated with TNF protein] results in increased expression of SOD2 protein]PMID:16366677
Ifngaffects expressionISOIfng (Mus musculus)6480464CTDGenistein affects the expression of IFNG mRNAPMID:14636701
Ifngdecreases secretionISOIfng (Mus musculus)6480464CTDGenistein results in decreased secretion of IFNG proteinPMID:14636701
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTDGenistein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CXCL8 mRNA]; Genistein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CXCL8 protein]; Genistein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF mRNA]; Genistein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]; Genistein inhibits the reaction [Oxygen deficiency results in increased expression of IFNG mRNA]PMID:15779068 PMID:23452621
Ifngmultiple interactionsISOIfng (Mus musculus)6480464CTDGenistein inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]PMID:12847270
Go Back to source page   Continue to Ontology report