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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2866
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:2682
Term: amphotericin B
Definition: A macrolide antibiotic used to treat potentially life-threatening fungal infections.
Chemical ID: MESH:D000666
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngincreases expressionISOIFNG (Homo sapiens)6480464CTDAmphotericin B analog results in increased expression of IFNG mRNAPMID:28534445
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTD[Amphotericin B co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; [Antimony Sodium Gluconate co-treated with Amphotericin B] results in increased expression of IFNG proteinPMID:17911647 PMID:29594315
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