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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstp1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:5864
Term: ifosfamide
Definition: The simplest member of the class of ifosfamides that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by 2-chloroethyl groups on both the nitrogen atoms respectively. It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer.
Chemical ID: MESH:D007069
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstp1affects response to substanceISOGSTP1 (Homo sapiens)6480464CTDGSTP1 gene polymorphism affects the susceptibility to IfosfamidePMID:12868187
Gstp1increases response to substanceISOGSTP1 (Homo sapiens)6480464CTDGSTP1 gene polymorphism results in increased susceptibility to IfosfamidePMID:16282887
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