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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstp1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:27656
Term: camptothecin
Definition: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Chemical ID: MESH:D002166
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstp1decreases response to substanceISOGSTP1 (Homo sapiens)6480464CTDGSTP1 protein polymorphism results in decreased susceptibility to Camptothecin; GSTP1 protein results in decreased susceptibility to CamptothecinPMID:14732228 PMID:15500952
Gstp1increases expressionISOGSTP1 (Homo sapiens)6480464CTDCamptothecin results in increased expression of GSTP1 proteinPMID:15500952
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