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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2692
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gja5
Name: gap junction protein, alpha 5
Acc ID: CHEBI:78510
Term: dorsomorphin
Definition: A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Chemical ID: MESH:C516138
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja5decreases expressionEXP 6480464CTDdorsomorphin results in decreased expression of GJA5 proteinPMID:33676887
Gja5multiple interactionsEXP 6480464CTDdorsomorphin inhibits the reaction [25-hydroxyprotopanaxadiol inhibits the reaction [AGT protein results in decreased expression of GJA5 protein]]PMID:33676887
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