Gene Term Annotation Report - Rat Genome Database

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GENE - TERM ANNOTATION REPORT

RGD ID:	2625
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Fnta
Name:	farnesyltransferase, CAAX box, subunit alpha

Acc ID:	GO:0004662
Term:	CAAX-protein geranylgeranyltransferase activity
Definition:	Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families.
Definition Source(s):	EC:2.5.1.59, PMID:8621375

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Fnta	contributes_to	IDA		2302973	RGD
Fnta	contributes_to	IBA	PANTHER:PTN000122903 or PomBase:SPAPB1A10.04c or Fnta (Rattus norvegicus)	1600115	GO_Central	GO_REF:0000033	GO_REF:0000033
Fnta	enables	IEA	EC:2.5.1.59	1600115	UniProt	GO_REF:0000003	GO_REF:0000003

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