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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2466
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b1
Name: cytochrome P450, family 2, subfamily b, polypeptide 1
Acc ID: CHEBI:8434
Term: prochloraz
Definition: A member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables.
Chemical ID: MESH:C045362
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b1increases activityEXP 6480464CTDprochloraz results in increased activity of CYP2B1 proteinPMID:25182419 PMID:29038839
Cyp2b1increases expressionEXP 6480464CTDprochloraz results in increased expression of CYP2B1 mRNAPMID:25182419 PMID:29038839
Cyp2b1multiple interactionsEXP 6480464CTD[prochloraz co-treated with epoxiconazole co-treated with cyproconazole] results in increased activity of CYP2B1 protein; [prochloraz co-treated with epoxiconazole co-treated with cyproconazole] results in increased expression of CYP2B1 mRNAPMID:29038839
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