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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrna3
Name: cholinergic receptor nicotinic alpha 3 subunit
Acc ID: CHEBI:132082
Term: entinostat
Definition: A member of the class of benzamides resulting from the formal condensation of the carboxy group of the pyridin-3-ylmethyl carbamate derivative of p-(aminomethyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an inhibitor of histone deacetylase isoform 1 (HDAC1) and isoform 3 (HDAC3).
Chemical ID: MESH:C118739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna3increases expressionISOCHRNA3 (Homo sapiens)6480464CTDentinostat results in increased expression of CHRNA3 mRNAPMID:26272509
Chrna3multiple interactionsISOCHRNA3 (Homo sapiens)6480464CTD[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHRNA3 mRNAPMID:27188386
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