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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2299
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd28
Name: Cd28 molecule
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd28increases abundanceISOCD28 (Homo sapiens)6480464CTDCD28 protein results in increased abundance of Reactive Oxygen SpeciesPMID:14607919
Cd28multiple interactionsISOCD28 (Homo sapiens)6480464CTD1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]; 2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]; 5-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]PMID:14607919
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