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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2085
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alb
Name: albumin
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Albdecreases expressionEXP 6480464CTDStreptozocin results in decreased expression of ALB proteinPMID:18204486 PMID:29331653 PMID:35187753 PMID:38047382
Albincreases expressionEXP 6480464CTDStreptozocin results in increased expression of ALB proteinPMID:12845431 PMID:21450970 PMID:25199697 PMID:33639173
Albmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Streptozocin] results in decreased expression of ALB protein; [Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of ALB protein; [Streptozocin co-treated with Cadmium] results in increased expression of ALB protein; [Streptozocin co-treated with Cholesterol, Dietary] results in increased secretion of ALB protein; [Streptozocin co-treated with Dietary Fats] results in increased expression of ALB protein; bisacurone inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of ALB protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; diphenyldiselenide inhibits the reaction [Streptozocin results in increased expression of ALB protein]; Eugenol inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Gallic Acid inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased secretion of ALB protein]; Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of ALB protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of ALB protein]; LR-90 inhibits the reaction [Streptozocin results in increased expression of ALB protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of ALB protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of ALB protein]; Plant Extracts inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of ALB protein]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of ALB protein]; Quercetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of ALB protein]PMID:12845431 PMID:14871415 PMID:18204486 PMID:24923654 PMID:25199697 PMID:25240712 PMID:29331653 PMID:33639173 PMID:34922902 PMID:35187753 PMID:36510688 PMID:38047382
Albincreases expressionISOAlb (Mus musculus)6480464CTDStreptozocin results in increased expression of ALB proteinPMID:30184259
Albincreases secretionISOAlb (Mus musculus)6480464CTDStreptozocin results in increased secretion of ALB proteinPMID:17360766
Albmultiple interactionsISOAlb (Mus musculus)6480464CTD[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in increased expression of ALB protein; AM6545 inhibits the reaction [Streptozocin results in increased expression of ALB protein]; naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in increased expression of ALB protein]; Perindopril inhibits the reaction [Streptozocin results in increased expression of ALB protein]; TXN protein inhibits the reaction [Streptozocin results in increased secretion of ALB protein]PMID:17360766 PMID:30184259 PMID:31063766
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