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GENE - TERM ANNOTATION REPORT

RGD ID: 18419741
Species: Chlorocebus sabaeus
RGD Object: Gene
Symbol: SLC12A3
Name: solute carrier family 12 member 3
Acc ID: DOID:4500
Term: hypokalemia
Definition: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
Definition Source(s): MESH:D007008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC12A3 ISOSLC12A3 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: HypokalemiaPMID:10988270 PMID:12039972 PMID:17329572 PMID:18391953 PMID:21415153 PMID:22009145 PMID:23328711 PMID:25741868 PMID:26467025 PMID:26921350 PMID:28492532 PMID:35591852 PMID:35628451 PMID:8528245 PMID:9734597
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