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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605980
Species: Homo sapiens
RGD Object: Gene
Symbol: SAMD4B
Name: sterile alpha motif domain containing 4B
Acc ID: CHEBI:40036
Term: amitrole
Definition: A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.
Chemical ID: MESH:D000640
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SAMD4Bdecreases expressionISOSamd4b (Rattus norvegicus)6480464CTDAmitrole results in decreased expression of SAMD4B mRNAPMID:38685447
SAMD4Bincreases expressionISOSamd4b (Rattus norvegicus)6480464CTDAmitrole results in increased expression of SAMD4B mRNAPMID:30047161
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