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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1604985
Species: Homo sapiens
RGD Object: Gene
Symbol: KLB
Name: klotho beta
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KLBincreases expressionISOKlb (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of KLB mRNAPMID:19770486 PMID:21889950 PMID:25975270
KLBmultiple interactionsISOKlb (Mus musculus)6480464CTD[AHR gene mutant form affects the susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of KLB mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of KLB mRNAPMID:25975270 PMID:29452137
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