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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1595860
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Acc ID: CHEBI:3908
Term: coumestrol
Definition: A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.
Chemical ID: MESH:D003375
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ezh2increases expressionISOEZH2 (Homo sapiens)6480464CTDCoumestrol results in increased expression of EZH2 mRNAPMID:19167446
Ezh2multiple interactionsISOEZH2 (Homo sapiens)6480464CTD[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of EZH2 mRNA; [Coumestrol co-treated with resveratrol] results in increased expression of EZH2 mRNAPMID:19167446
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