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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583832
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgd
Name: phosphogluconate dehydrogenase
Acc ID: CHEBI:7731
Term: ofloxacin
Definition: A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Chemical ID: MESH:D015242
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgddecreases activityEXP 6480464CTDOfloxacin results in decreased activity of PGD proteinPMID:15558954
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